compounds chemdiv small molecule database Search Results


biacore t200 spr system  (Cytiva Europe)
99
Cytiva Europe biacore t200 spr system
Biacore T200 Spr System, supplied by Cytiva Europe, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/custom-28975001-34839161?v=Cytiva+Europe
Average 99 stars, based on 1 article reviews
biacore t200 spr system - by Bioz Stars, 2026-07
99/100 stars
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small molecule compounds cb6  (Chembridge)
86
Chembridge small molecule compounds cb6
Identification of SMIs. Chemical structures of MCCB5, <t>CB6</t> and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).
Small Molecule Compounds Cb6, supplied by Chembridge, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/pmc12668607-55-2-11?v=Chembridge
Average 86 stars, based on 1 article reviews
small molecule compounds cb6 - by Bioz Stars, 2026-07
86/100 stars
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libraries small molecules  (ASINEX Inc)
90
ASINEX Inc libraries small molecules
Identification of SMIs. Chemical structures of MCCB5, <t>CB6</t> and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).
Libraries Small Molecules, supplied by ASINEX Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/pmc02920070-266-16-12?v=ASINEX+Inc
Average 90 stars, based on 1 article reviews
libraries small molecules - by Bioz Stars, 2026-07
90/100 stars
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molecule compounds  (Chemdiv Inc)
86
Chemdiv Inc molecule compounds
Identification of SMIs. Chemical structures of MCCB5, <t>CB6</t> and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).
Molecule Compounds, supplied by Chemdiv Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/pm42049720-400-2-13?v=Chemdiv+Inc
Average 86 stars, based on 1 article reviews
molecule compounds - by Bioz Stars, 2026-07
86/100 stars
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biacore insight software  (Cytiva Europe)
94
Cytiva Europe biacore insight software
Identification of SMIs. Chemical structures of MCCB5, <t>CB6</t> and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).
Biacore Insight Software, supplied by Cytiva Europe, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/custom-29310602-34839161?v=Cytiva+Europe
Average 94 stars, based on 1 article reviews
biacore insight software - by Bioz Stars, 2026-07
94/100 stars
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biacore  (Cytiva Europe)
99
Cytiva Europe biacore
Identification of SMIs. Chemical structures of MCCB5, <t>CB6</t> and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).
Biacore, supplied by Cytiva Europe, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compounds+chemdiv+small+molecule+database/custom-br110073-34839161?v=Cytiva+Europe
Average 99 stars, based on 1 article reviews
biacore - by Bioz Stars, 2026-07
99/100 stars
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Image Search Results


Identification of SMIs. Chemical structures of MCCB5, CB6 and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).

Journal: The Journal of General Virology

Article Title: Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription

doi: 10.1099/jgv.0.002183

Figure Lengend Snippet: Identification of SMIs. Chemical structures of MCCB5, CB6 and MJM364 and predicted docking poses. Three hydrophobic hotspots were identified as important for the NP:VP35 interaction. Compounds were screened in silico using the eHiTs exhaustive docking engine, AutoDock cluster analysis and pose prediction software or de novo designed (see also Fig. S1A, available in the online Supplementary Material).

Article Snippet: Commercially available small molecule compounds CB6 and MCCB5 were purchased from ChemBridge ( https://www.hit2lead.com/ ) and Asinex ChemDiv ( http://www.chemdiv.com/ ), respectively, and compound purity was assessed by LC-MS (Thermo Scientific Ultimate 3000 HPLC system equipped with a Bruker amaZon Speed mass spectrometer).

Techniques: In Silico, Software

Activity of MCCB5, CB6 and MJM364. Compounds were tested for activity against the T7FFLuc control, the BUNV or the EBOV MG. The compounds were added to BSR-T7 cells at the indicated concentrations immediately before transfection. Cells were harvested at 24 hpt and analysed for FF-luc (EBOV MG and T7FFLuc control) or R-luc (BUNV MG), or cell viability by MTT assay. Values are represented as percentages of a transfection-only control. Graphs show dose–response curves for % RLU (left) and cytotoxicity (right). (a) MCCB5, (b) CB6 and (c) MJM364. EBOV, red circles. T7FFLuc control, blue squares. BUNV control, black diamonds. Averages plotted from three independent experiments performed in triplicate. Error bars show sd .

Journal: The Journal of General Virology

Article Title: Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription

doi: 10.1099/jgv.0.002183

Figure Lengend Snippet: Activity of MCCB5, CB6 and MJM364. Compounds were tested for activity against the T7FFLuc control, the BUNV or the EBOV MG. The compounds were added to BSR-T7 cells at the indicated concentrations immediately before transfection. Cells were harvested at 24 hpt and analysed for FF-luc (EBOV MG and T7FFLuc control) or R-luc (BUNV MG), or cell viability by MTT assay. Values are represented as percentages of a transfection-only control. Graphs show dose–response curves for % RLU (left) and cytotoxicity (right). (a) MCCB5, (b) CB6 and (c) MJM364. EBOV, red circles. T7FFLuc control, blue squares. BUNV control, black diamonds. Averages plotted from three independent experiments performed in triplicate. Error bars show sd .

Article Snippet: Commercially available small molecule compounds CB6 and MCCB5 were purchased from ChemBridge ( https://www.hit2lead.com/ ) and Asinex ChemDiv ( http://www.chemdiv.com/ ), respectively, and compound purity was assessed by LC-MS (Thermo Scientific Ultimate 3000 HPLC system equipped with a Bruker amaZon Speed mass spectrometer).

Techniques: Activity Assay, Control, Transfection, MTT Assay

Time-course analysis of MCCB5, CB6 and MJM364 activity. (a) Compounds were analysed at their relative EC 50 values. Samples were harvested at the indicated times hpt, and values are represented as percentages of a transfection-only control. (b) A time-of-addition study was undertaken at the relative EC 75 concentrations of the compounds. The top panel is a schematic demonstrating when the compounds were present during transfection. The graph shows the data as a percentage of a transfection-only DMSO control, harvested at the same time. All averages were plotted from three independent experiments performed in triplicate and compared using an unpaired two-tailed t-test. Error bars show sd . **** P <0.0001, *** P 0.001 and ** P 0.01.

Journal: The Journal of General Virology

Article Title: Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription

doi: 10.1099/jgv.0.002183

Figure Lengend Snippet: Time-course analysis of MCCB5, CB6 and MJM364 activity. (a) Compounds were analysed at their relative EC 50 values. Samples were harvested at the indicated times hpt, and values are represented as percentages of a transfection-only control. (b) A time-of-addition study was undertaken at the relative EC 75 concentrations of the compounds. The top panel is a schematic demonstrating when the compounds were present during transfection. The graph shows the data as a percentage of a transfection-only DMSO control, harvested at the same time. All averages were plotted from three independent experiments performed in triplicate and compared using an unpaired two-tailed t-test. Error bars show sd . **** P <0.0001, *** P 0.001 and ** P 0.01.

Article Snippet: Commercially available small molecule compounds CB6 and MCCB5 were purchased from ChemBridge ( https://www.hit2lead.com/ ) and Asinex ChemDiv ( http://www.chemdiv.com/ ), respectively, and compound purity was assessed by LC-MS (Thermo Scientific Ultimate 3000 HPLC system equipped with a Bruker amaZon Speed mass spectrometer).

Techniques: Activity Assay, Transfection, Control, Two Tailed Test

MCCB5, CB6 and MJM364 activity in Huh7-Lunet-T7 cells. Compounds were tested for activity against the EBOV MG or T7FFLuc control. The compounds were added to Huh7-Lunet-T7 cells at the indicated concentrations immediately before transfection. Cells were harvested at 24 hpt and analysed for FF-luc, or cell viability by MTT assay. Values are represented as percentages of a transfection-only control. Graphs show dose–response curves for % RLU (left) and cytotoxicity (right). (a) MCCB5, (b) CB6 and (c) MJM364. EBOV, red circles. T7FFLuc control, blue squares. Averages were plotted from three independent experiments performed in triplicate. Error bars show sd .

Journal: The Journal of General Virology

Article Title: Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription

doi: 10.1099/jgv.0.002183

Figure Lengend Snippet: MCCB5, CB6 and MJM364 activity in Huh7-Lunet-T7 cells. Compounds were tested for activity against the EBOV MG or T7FFLuc control. The compounds were added to Huh7-Lunet-T7 cells at the indicated concentrations immediately before transfection. Cells were harvested at 24 hpt and analysed for FF-luc, or cell viability by MTT assay. Values are represented as percentages of a transfection-only control. Graphs show dose–response curves for % RLU (left) and cytotoxicity (right). (a) MCCB5, (b) CB6 and (c) MJM364. EBOV, red circles. T7FFLuc control, blue squares. Averages were plotted from three independent experiments performed in triplicate. Error bars show sd .

Article Snippet: Commercially available small molecule compounds CB6 and MCCB5 were purchased from ChemBridge ( https://www.hit2lead.com/ ) and Asinex ChemDiv ( http://www.chemdiv.com/ ), respectively, and compound purity was assessed by LC-MS (Thermo Scientific Ultimate 3000 HPLC system equipped with a Bruker amaZon Speed mass spectrometer).

Techniques: Activity Assay, Control, Transfection, MTT Assay

Mutagenic analysis of NP confirms the interaction of MCCB5, CB6 and MJM365. (a) The EBOV NP hotspot residues: Val250, Lys274, Phe280 and Leu284 were mutated to alanine (V250A, K274A, F280A and L284A, respectively). The compounds were added to cells at the indicated concentrations immediately before transfection with either WT EBOV NP, mutant V250A, F280A or L284A. Cells were harvested at 24 hpt and analysed for FF-luc. (b–d) Cells were also treated with mycophenolic acid (MPA) at the previously defined EC 90 concentration, and this is shown as a single point for WT and the three mutants. Dose–response curves for MCCB5 ( b ), CB6 ( c ) and MJM364 ( d ). Left-hand graphs show % RLU represented as % of a transfection-only control. Right-hand graphs show a comparison of EC 50 values generated from the WT or mutant NP transfections. EC 50 values shown are from three independent experiments performed in triplicate compared using an unpaired two-tailed t-test. Error bars show sd . *** P <0.001 and **** P <0.0001.

Journal: The Journal of General Virology

Article Title: Discovery of three small-molecule inhibitors targeting Ebolavirus genome replication and transcription

doi: 10.1099/jgv.0.002183

Figure Lengend Snippet: Mutagenic analysis of NP confirms the interaction of MCCB5, CB6 and MJM365. (a) The EBOV NP hotspot residues: Val250, Lys274, Phe280 and Leu284 were mutated to alanine (V250A, K274A, F280A and L284A, respectively). The compounds were added to cells at the indicated concentrations immediately before transfection with either WT EBOV NP, mutant V250A, F280A or L284A. Cells were harvested at 24 hpt and analysed for FF-luc. (b–d) Cells were also treated with mycophenolic acid (MPA) at the previously defined EC 90 concentration, and this is shown as a single point for WT and the three mutants. Dose–response curves for MCCB5 ( b ), CB6 ( c ) and MJM364 ( d ). Left-hand graphs show % RLU represented as % of a transfection-only control. Right-hand graphs show a comparison of EC 50 values generated from the WT or mutant NP transfections. EC 50 values shown are from three independent experiments performed in triplicate compared using an unpaired two-tailed t-test. Error bars show sd . *** P <0.001 and **** P <0.0001.

Article Snippet: Commercially available small molecule compounds CB6 and MCCB5 were purchased from ChemBridge ( https://www.hit2lead.com/ ) and Asinex ChemDiv ( http://www.chemdiv.com/ ), respectively, and compound purity was assessed by LC-MS (Thermo Scientific Ultimate 3000 HPLC system equipped with a Bruker amaZon Speed mass spectrometer).

Techniques: Transfection, Mutagenesis, Concentration Assay, Control, Comparison, Generated, Two Tailed Test